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Article

Hypoxia-inducible factors, hypoxia, and tumor angiogenesis.

Current opinion in hematology - 1 May 2006

Gruber Michaela, Simon M Celeste

Abstract excerpt

PURPOSE OF REVIEW: The transcription factor hypoxia-inducible factor is activated by low oxygen to promote the expression of target genes that allow cellular, tissue, and organismal adaptation to low oxygen. Hypoxia-inducible factor is activated not only by hypoxia but also as a consequence of genetic mutations in a variety of tumors. This review summarizes recent studies on hypoxia-inducible factor-alpha...

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Identifiers

PMID: 16567961
DOI: 10.1097/01.moh.0000219663.88409.35

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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