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Article

Hypoxic downregulation of cellular proliferation and loss of phenotype stability in human osteoblasts is mediated by HIF-1α.

Clinical hemorheology and microcirculation - 1 Jan 2011

Lechler Philipp, Klein Silvan M, Prantl Lukas, Englert Carsten, Renkawitz Tobias, Grifka Joachim

Abstract excerpt

Both, skeletal development and fracture healing depend on an orchestrated sequence of cellular growth and differentiation processes. Regional changes in tissue oxygen tension were proposed as key regulators of osteoblast proliferation and phenotype. Hypoxia results in the stabilization of hypoxia-inducible factor-1α (HIF-1α), thus influencing expression of a multitude of genes required for cellular adaptation. In...

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Identifiers

PMID: 22214699
DOI: 10.3233/CH-2011-1478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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