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Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

30 Mar 2016

Abstract excerpt

Hypoxia and inflammation are implicated in the episodic induction of heterotopic endochondral ossification (HEO); however, the molecular mechanisms are unknown. HIF-1α integrates the cellular response to both hypoxia and inflammation and is a prime candidate for regulating HEO. We investigated the role of hypoxia and HIF-1α in fibrodysplasia ossificans progressiva (FOP), the most catastrophic form of HEO in...

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PMID: 27027798
DOI: 10.1002/jbmr.2848

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