Repression of Ets-2-Induced Transactivation of the Tau Interferon Promoter by Oct-4

doi:10.1128/mcb.21.23.7883-7891.2001

Article

Repression of Ets-2-Induced Transactivation of the Tau Interferon Promoter by Oct-4

1 Dec 2001

Abstract excerpt

Oct-4 is a POU family transcription factor associated with potentially totipotent cells. Genes expressed in the trophectoderm but not in embryos prior to blastocyst formation may be targets for silencing by Oct-4. Here, we have tested this hypothesis with the tau interferon genes (IFNT genes), which are expressed exclusively in the trophectoderm of bovine embryos. IFNT promoters contain an Ets-2 enhancer, located...

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