Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PACT-mediated enhancement of reporter gene expression at the translational level.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Dec 2003

Li Shoudong, Sen Ganes C

Abstract excerpt

The cellular protein, PACT, can directly activate protein kinase (PKR) in vitro by the interaction of PACT domain 3 with PKR. In contrast, in vivo, PACT-mediated PKR activation and concomitant inhibition of protein synthesis require additional cellular stresses. We observed that without such stre...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Genes, Reporter
Share to Interferon-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Fragments

Share to Phosphorylation

Share to Protein Biosynthesis

Share to Protein Structure, Tertiary

Share to RNA-Binding Proteins

Source

Identifiers

PMID: 14769145
DOI: 10.1089/107999003772084806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14769145-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PACT-mediated enhancement of reporter gene expression at the translational level.PMID 14769145Read ↗

The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).Semantic proximity Read ↗

Expression of PACT is regulated by Sp1 transcription factor.Semantic proximity Read ↗

Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis.Semantic proximity Read ↗

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.Semantic proximity Read ↗

Molecular basis for PKR activation by PACT or dsRNA.Semantic proximity Read ↗

A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell.Semantic proximity Read ↗

Translational up-regulation of polycystic kidney disease protein PKD2 by endoplasmic reticulum stress.Semantic proximity Read ↗

Human PKR transfected into murine cells stimulates expression of genes under control of the HIV1 or HTLV-I LTR.Semantic proximity Read ↗

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.Semantic proximity Read ↗

The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR.Semantic proximity Read ↗

Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line.Semantic proximity Read ↗

PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.