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Article

Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter.

Biochimica et biophysica acta - 22 Dec 1998

Gay R D, Dawson S J, Murphy W J, Russell S W, Latchman D S

Abstract excerpt

The promoter of the gene encoding the inducible nitric oxide synthase (iNOS) contains an octamer motif which is of importance for its activation by specific stimuli. We show that in contrast to the promoter of the neuronal nitric oxide synthase gene (nNOS) which is strongly activated by the Oct-2...

Topics

Animals
Binding Sites
Cell Line
DNA-Binding Proteins
Gene Expression Regulation
Genetic Vectors
Homeodomain Proteins
Mutation
Nitric Oxide Synthase
Nitric Oxide Synthase Type II
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Fusion Proteins

Transcription Factor Brn-3

Transcription Factor Brn-3B

Transcription Factors

Source

Identifiers

PMID: 9878805
DOI: 10.1016/s0167-4781(98)00234-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9878805-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter.PMID 9878805Read ↗

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