Article
Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption.
Development (Cambridge, England) - 1 Aug 2001
Feiner L, Webber A L, Brown C B, Lu M M, Jia L, Feinstein P, Mombaerts P, Epstein J A, Raper J A
Abstract excerpt
Semaphorin 3C is a secreted member of the semaphorin gene family. To investigate its function in vivo, we have disrupted the semaphorin 3C locus in mice by targeted mutagenesis. semaphorin 3C mutant mice die within hours after birth from congenital cardiovascular defects consisting of interruption of the aortic arch and improper septation of the cardiac outflow tract. This phenotype is similar to that reported...
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