Accumulated background variation among H2 mutant congenic strains: elimination through PCR-based genotyping of F2 segregants.

Abstract excerpt

Many commercially and privately available congenic strains of laboratory animals were founded decades ago and are likely to differ from one another by dozens of fixed mutational differences at background loci. This problem is often ignored despite growing evidence that such background variation exists. Eliminating this confounding variation can be largely accomplished by crossing congenic strains to produce F2...

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