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Article

Novel insights into the genetic background of genetically modified mice.

Transgenic research - 1 Jun 2018

Dobrowolski Peter, Fischer Melina, Naumann Ronald

Abstract excerpt

Unclear or misclassified genetic background of laboratory rodents or a lack of strain awareness causes a number of difficulties in performing or reproducing scientific experiments. Until now, genetic differentiation between strains and substrains of inbred mice has been a challenge. We have developed a screening method for analyzing inbred strains regarding their genetic background. It is based on 240 highly...

Topics

Animals
Animals, Genetically Modified
Chromosomes
Genetic Background
Haplotypes
Mice
Mice, Inbred Strains
Mice, Transgenic
Microsatellite Repeats
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29663254
DOI: 10.1007/s11248-018-0073-2

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