Article
Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice.
Nature genetics - 1 May 1997
Simpson E M, Linder C C, Sargent E E, Davisson M T, Mobraaten L E, Sharp J J
Abstract excerpt
Targeted mutagenesis in mice, a powerful tool for the analysis of gene function and human disease, makes extensive use of 129 mouse substrains. Although all are named 129, we document that outcrossing of these substrains, both deliberate and accidental, has lead to extensive genetic variability among substrains and embryonic stem cells derived from them. This clearer understanding of 129 substrain variability...
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