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Article

Molecular basis for Rho GTPase signaling specificity.

Breast cancer research and treatment - 1 Mar 2004

Karnoub Antoine E, Symons Marc, Campbell Sharon L, Der Channing J

Abstract excerpt

There is now considerable evidence for the involvement of aberrant Rho GTPase activation in breast cancer development. Like Ras, Rho GTPases function as signaling nodes regulated by diverse extracellular stimuli. Rho GTPase activation is facilitated by multiple regulatory proteins, in particular guanine nucleotide exchange factors (GEFs) such as Dbl family proteins. Activated Rho GTPases in turn interact with and...

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Identifiers

PMID: 14999155
DOI: 10.1023/B:BREA.0000018427.84929.5c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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