Article
Population genetic structure of variable drug response.
Nature genetics - 1 Nov 2001
Wilson J F, Weale M E, Smith A C, Gratrix F, Fletcher B, Thomas M G, Bradman N, Goldstein D B
Abstract excerpt
Geographic patterns of genetic variation, including variation at drug metabolizing enzyme (DME) loci and drug targets, indicate that geographic structuring of inter-individual variation in drug response may occur frequently. This raises two questions: how to represent human population genetic structure in the evaluation of drug safety and efficacy, and how to relate this structure to drug response. We address...
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