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Article

Population structure and pharmacogenomic risk stratification in the United States.

BMC biology - 13 Oct 2020

Nagar Shashwat Deepali, Conley Andrew B, Jordan I King

Abstract excerpt

BACKGROUND: Pharmacogenomic (PGx) variants mediate how individuals respond to medication, and response differences among racial/ethnic groups have been attributed to patterns of PGx diversity. We hypothesized that genetic ancestry (GA) would provide higher resolution for stratifying PGx risk, since it serves as a more reliable surrogate for genetic diversity than self-identified race/ethnicity (SIRE), which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33050895
DOI: 10.1186/s12915-020-00875-4
PMCID: PMC7557099

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