Article

A Framework to Quantify Disparities in Pharmacogenomic Treatment Concordance and Drug Response Outcomes

2025-09-30

Abstract excerpt

Clinical PGx practice guidelines (PGx guidelines) may have limited generalizability for “marginalized” groups. We proposed the five-step Real-World Data for Genome-Guided Prescribing (ReGGRx) framework and, using All of Us research program (AoU) data, examined its ability to estimate disparities in concordance with and benefit from PGx guidelines for CYP2C19 testing when choosing antiplatelet and antidepressant dr...

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Literature Corpus work: f1b8193c-ee80-5c5f-84a3-757b79698221
DOI: 10.1101/2025.09.29.25335264

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