Article
A Framework to Quantify Disparities in Pharmacogenomic Treatment Concordance and Drug Response Outcomes.
Clinical and translational science - 1 Feb 2026
Rattsev Ilia, Stevenson James M, Taylor Casey Overby
Abstract excerpt
Clinical PGx practice guidelines (PGx guidelines) may have limited generalizability for "marginalized" groups. We proposed the five-step Real-World Data for Genome-Guided Prescribing (ReGGRx) framework and, using All of Us research program (AoU) data, examined its ability to estimate disparities in concordance with and benefit from PGx guidelines for CYP2C19 testing when choosing antiplatelet and antidepressant...
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