Article
Group-based pharmacogenetic prediction: is it feasible and do current NHS England ethnic classifications provide appropriate data?
The pharmacogenomics journal - 1 Feb 2021
Ingram Catherine J E, Ekong Rosemary, Ansari-Pour Naser, Bradman Neil, Swallow Dallas M
Abstract excerpt
Inter-individual variation of drug metabolising enzymes (DMEs) leads to variable efficacy of many drugs and even adverse drug responses. Consequently, it would be desirable to test variants of many DMEs before drug treatment. Inter-ethnic differences in frequency mean that the choice of SNPs to test may vary across population groups. Here we examine the utility of testing representative groups as a way of...
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