Article
Mother-to-child discordance in HLA-G exon 2 is associated with a reduced risk of perinatal HIV-1 transmission.
AIDS (London, England) - 9 Nov 2001
Aikhionbare F O, Hodge T, Kuhn L, Bulterys M, Abrams E J, Bond V C
Abstract excerpt
Definitive genetic parameters correlating with mother-to-child transmission (MCT) of HIV have not been fully established. We screened for the potential correlation between HLA-G variants and MCT, in a cohort of mother-child pairs. Discordance in exon 2 of HLA-G was significantly more common among non-transmitting (93%) than transmitting mother-child pairs (40%). Our results suggest that mother-child pairs both...
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