Article
HLA-G and mother-child perinatal HIV transmission.
Human immunology - 1 Apr 2013
Luo Ma, Czarnecki Chris, Ramdahin Suzie, Embree Joanne, Plummer Francis A
Abstract excerpt
Transplacental passage is a well-known phenomenon in HIV infection and immune responses at the maternal-fetal interface play a critical role in perinatal mother-to-child HIV transmission (MCHT). The high expression of HLA-G at the maternal-fetal interface and its role in mediating immune tolerance suggest that it could play an important role in MCHT. We investigated the role of HLA-G polymorphism in perinatal HIV...
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