Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts.

doi:10.1038/sj.onc.1203236

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Article

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts.

Oncogene - 22 Nov 1999

Gerondakis S, Grossmann M, Nakamura Y, Pohl T, Grumont R

Abstract excerpt

Rel/NF-kappaB transcription factors have been implicated in regulating a wide variety of genes important in cellular processes that include cell division, cell survival, differentiation and immunity. Here genetic models in which various Rel/NF-kappaB and IkappaB proteins have either been over-expressed or deleted in mice will be reviewed. Although expressed fairly ubiquitously, homozygous disruption of individual...

Topics

Animals
B-Cell Lymphoma 3 Protein
I-kappa B Kinase
Mice
Mice, Knockout
Mice, Transgenic
Mutation
NF-kappa B
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins
Transcription Factor RelA
Transcription Factor RelB
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 10602464
DOI: 10.1038/sj.onc.1203236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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