Article
Genetic loci associated with an earlier age at onset in multiplex schizophrenia.
Scientific reports - 25 Jul 2017
Woolston Annemarie L, Hsiao Po-Chang, Kuo Po-Hsiu, Wang Shi-Heng, Lien Yin-Ju, Liu Chih-Min, Hwu Hai-Gwo, Lu Tzu-Pin, Chuang Eric Y, Chang Li-Ching, Chen Chien-Hsiun, Wu Jer-Yuarn, Tsuang Ming T, Chen Wei J
Abstract excerpt
An earlier age at onset (AAO) has been associated with greater genetic loadings in schizophrenia. This study aimed to identify modifier loci associated with an earlier AAO of schizophrenia. A genome-wide association analysis (GWAS) was conducted in 94 schizophrenia probands with the earliest AAO and 91 with the latest AAO. Candidate single nucleotide polymorphisms (SNPs) were then genotyped in the co-affected...
Topics
- Adult
- Age of Onset
- Aged
- Case-Control Studies
- Female
- Genetic Loci
- Genetic Markers
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Middle Aged