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Article

Genetic loci associated with an earlier age at onset in multiplex schizophrenia.

Scientific reports - 25 Jul 2017

Woolston Annemarie L, Hsiao Po-Chang, Kuo Po-Hsiu, Wang Shi-Heng, Lien Yin-Ju, Liu Chih-Min, Hwu Hai-Gwo, Lu Tzu-Pin, Chuang Eric Y, Chang Li-Ching, Chen Chien-Hsiun, Wu Jer-Yuarn, Tsuang Ming T, Chen Wei J

Abstract excerpt

An earlier age at onset (AAO) has been associated with greater genetic loadings in schizophrenia. This study aimed to identify modifier loci associated with an earlier AAO of schizophrenia. A genome-wide association analysis (GWAS) was conducted in 94 schizophrenia probands with the earliest AAO and 91 with the latest AAO. Candidate single nucleotide polymorphisms (SNPs) were then genotyped in the co-affected...

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Identifiers

PMID: 28744025
DOI: 10.1038/s41598-017-06795-8
PMCID: PMC5527118

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Source receipt: pubmed, retrieved 7 Sept 2026.

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