Drosophila synaptotagmin I null mutants survive to early adulthood.

doi:10.1002/gene.10002

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Drosophila synaptotagmin I null mutants survive to early adulthood.

Genesis (New York, N.Y. : 2000) - 1 Sept 2001

Loewen C A, Mackler J M, Reist N E

Abstract excerpt

Synaptotagmin is a synaptic vesicle protein required for efficient neurotransmitter release, yet its exact role in the synaptic vesicle cycle is unclear. Drosophila presents an ideal organism for studies aimed at determining the in vivo functions of proteins. However, synaptotagmin studies have been limited by the early (embryonic or first instar) lethality previously reported for Drosophila synaptotagmin I null...

Topics

Animals
Animals, Genetically Modified
Behavior, Animal
Calcium-Binding Proteins
Drosophila
Electrophysiology
Genes, Lethal
Immunoblotting
Immunoenzyme Techniques
In Vitro Techniques
Larva

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Fusion

Membrane Glycoproteins

Mutagenesis, Site-Directed

Nerve Tissue Proteins

Neurotransmitter Agents

Phenotype

Survival Rate

Source

Open in PubMed

Identifiers

PMID: 11668675
DOI: 10.1002/gene.10002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila synaptotagmin I null mutants survive to early adulthood.PMID 11668675Read ↗

Drosophila synaptotagmin I null mutants show severe alterations in vesicle populations but calcium-binding motif mutants do not.Semantic proximity Read ↗

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.Semantic proximity Read ↗

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.Semantic proximity Read ↗

Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release.Semantic proximity Read ↗

Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants.Semantic proximity Read ↗

The effect on synaptic physiology of synaptotagmin mutations in Drosophila.Semantic proximity Read ↗

Developmental arrest of Drosophila larvae elicits presynaptic depression and enables prolonged studies of neurodegeneration.Semantic proximity Read ↗

Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.Semantic proximity Read ↗

Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.Semantic proximity Read ↗

Quantitative analysis of synaptic boutons in Drosophila primary neuronal cultures.Semantic proximity Read ↗

Drosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization.Semantic proximity Read ↗

Synaptogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.