Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.

doi:10.1016/0092-8674(93)90733-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.

Cell - 24 Sept 1993

Littleton J T, Stern M, Schulze K, Perin M, Bellen H J

Abstract excerpt

Synaptotagmin (syt), a synaptic vesicle-specific protein known to bind Ca2+ in the presence of phospholipids, has been proposed to mediate Ca(2+)-dependent neurotransmitter release. We have addressed the role of syt in neurotransmitter release in vivo by generating mutations in synaptotagmin (syt...

Topics

Alleles
Animals
Calcium
Calcium-Binding Proteins
DNA Mutational Analysis
DNA, Complementary
Drosophila
Embryo, Nonmammalian
Ethyl Methanesulfonate
Evoked Potentials
Heterozygote
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Larva

Membrane Glycoproteins

Mutagenesis

Nerve Tissue Proteins

Neuromuscular Junction

Neurotransmitter Agents

Source

Open in PubMed

Identifiers

PMID: 8104705
DOI: 10.1016/0092-8674(93)90733-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8104705-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.PMID 8104705Read ↗

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.Semantic proximity Read ↗

Drosophila synaptotagmin I null mutants survive to early adulthood.Semantic proximity Read ↗

External Ca2+ dependency of synaptic transmission in drosophila synaptotagmin I mutants.Semantic proximity Read ↗

The effect on synaptic physiology of synaptotagmin mutations in Drosophila.Semantic proximity Read ↗

Drosophila synaptotagmin I null mutants show severe alterations in vesicle populations but calcium-binding motif mutants do not.Semantic proximity Read ↗

Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin.Semantic proximity Read ↗

Disease-causing mutations in Synaptotagmin can act via dominant-negative, gain-of-function or haploinsufficient mechanismsSemantic proximity Read ↗

Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.Semantic proximity Read ↗

Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.Semantic proximity Read ↗

Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.Semantic proximity Read ↗

Cysteine-string protein increases the calcium sensitivity of neurotransmitter exocytosis in Drosophila.Semantic proximity Read ↗

Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca(2+)-dependent manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.