Article
Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 1996
McMahon H T, Bolshakov V Y, Janz R, Hammer R E, Siegelbaum S A, Südhof T C
Abstract excerpt
Synaptophysin (syp I) is a synaptic vesicle membrane protein that constitutes approximately 7% of the total vesicle protein. Multiple lines of evidence implicate syp I in a number of nerve terminal functions. To test these, we have disrupted the murine Syp I gene. Mutant mice lacking syp I were viable and fertile. No changes in the structure and protein composition of the mutant brains were observed except for a...
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