Article
Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 1996
McMahon H T, Bolshakov V Y, Janz R, Hammer R E, Siegelbaum S A, Südhof T C
Abstract excerpt
Synaptophysin (syp I) is a synaptic vesicle membrane protein that constitutes approximately 7% of the total vesicle protein. Multiple lines of evidence implicate syp I in a number of nerve terminal functions. To test these, we have disrupted the murine Syp I gene. Mutant mice lacking syp I were v...
Topics
- Animals
- Base Sequence
- Calcium
- Chromosome Mapping
- DNA Primers
- Electrophysiology
- Humans
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Neuronal Plasticity
- Neurotransmitter Agents
- Phenotype
- Synaptic Transmission
- Synaptic Vesicles
- Synaptophysin