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Article

The effect on synaptic physiology of synaptotagmin mutations in Drosophila.

Neuron - 1 Apr 1994

DiAntonio A, Schwarz T L

Abstract excerpt

Synaptotagmin is a synaptic vesicle protein implicated in neurotransmitter release. Molecular characterization of four mutant alleles of this protein in Drosophila melanogaster has permitted an investigation of synaptotagmin's role in synaptic physiology and of some of the structural requirements for its function. Reduced levels of synaptotagmin resulted in a substantial alteration in synaptic function in the eye...

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PMID: 7909234
DOI: 10.1016/0896-6273(94)90342-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The effect on synaptic physiology of synaptotagmin mutations in Drosophila.PMID 7909234Read ↗

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Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.Semantic proximity Read ↗

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Drosophila synaptotagmin I null mutants survive to early adulthood.Semantic proximity Read ↗

Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.Semantic proximity Read ↗

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.Semantic proximity Read ↗

Genetic analysis of neurotransmitter release at the synapse.Semantic proximity Read ↗

Drosophila synaptotagmin I null mutants show severe alterations in vesicle populations but calcium-binding motif mutants do not.Semantic proximity Read ↗

Drosophila alpha- and beta-spectrin mutations disrupt presynaptic neurotransmitter release.Semantic proximity Read ↗

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Selective effects of neuronal-synaptobrevin mutations on transmitter release evoked by sustained versus transient Ca2+ increases and by cAMP.Semantic proximity Read ↗

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