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Article

Developmental arrest of Drosophila larvae elicits presynaptic depression and enables prolonged studies of neurodegeneration.

Development (Cambridge, England) - 21 May 2020

Perry Sarah, Goel Pragya, Tran Nancy L, Pinales Cristian, Buser Christopher, Miller Daniel L, Ganetzky Barry, Dickman Dion

Abstract excerpt

Synapses exhibit an astonishing degree of adaptive plasticity in healthy and disease states. We have investigated whether synapses also adjust to life stages imposed by novel developmental programs for which they were never molded by evolution. Under conditions in which Drosophila larvae are terminally arrested, we have characterized synaptic growth, structure and function at the neuromuscular junction (NMJ)....

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Identifiers

PMID: 32345746
DOI: 10.1242/dev.186312
PMCID: PMC7325439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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