Article
Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice.
Alcohol (Fayetteville, N.Y.) - 1 Jan 2003
Saito Mariko, Ehringer Marissa A, Toth Reka, Oros Melinda, Szakall Istvan, Sikela James M, Vadasz Csaba
Abstract excerpt
Results of recent studies have indicated an association between voluntary alcohol intake and activities of kappa-opioid receptor systems in animal models. We assessed the possibility that genetic differences observed in alcohol preference among mouse strains are related to possible polymorphisms of the kappa-opioid receptor gene (Oprk1). We compared DNA sequences of the coding region and the promoter/regulatory...
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