Article
Polymorphisms of interleukin-10 and its receptor and lung function in COPD.
The European respiratory journal - 1 Jun 2007
He J-Q, Shumansky K, Zhang X, Connett J E, Anthonisen N R, Sandford A J
Abstract excerpt
Interleukin (IL)-10 is a type-2 T-helper cell cytokine with a broad spectrum of anti-inflammatory actions. Inflammation plays an important role in the pathogenesis of chronic obstructive pulmonary disease. It was hypothesised that single nucleotide polymorphisms (SNPs) of the genes encoding IL-10 (IL10) and the alpha subunit of its receptor (IL10RA) are associated with changes in, or value of, forced expiratory...
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