Article
Association of the interleukin-1 receptor antagonist gene with asthma.
American journal of respiratory and critical care medicine - 1 Jun 2004
Gohlke Henning, Illig Thomas, Bahnweg Margret, Klopp Norman, André Elisabeth, Altmüller Janine, Herbon Nicole, Werner Monika, Knapp Michael, Pescollderungg Lydia, Boner Attilio, Malerba Giovanni, Pignatti Pier Franco, Wjst Matthias
Abstract excerpt
The interleukin-1 cluster on human chromosome 2q12-2q14 harbors various promising candidate genes for asthma and other inflammatory diseases. We conducted a systematic association study with single-nucleotide polymorphisms (SNPs) located in candidate genes situated in this cluster. Single-marker, two-locus and three-locus haplotype analysis of SNPs yielded several significant results (p < 0.05-0.0021) for the...
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