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Article

Activation of Pregnane X Receptor and Induction of MDR1 by Dietary Phytochemicals

10 Jun 2008

Abstract excerpt

The pregnane X receptor (PXR) is understood to be the key regulator for gene expression of such drug-metabolizing enzymes and transporters as multidrug-resistant protein 1 (MDR1) and the cytochrome P450 (CYP) family. We examined the effect of dietary phytochemicals on the PXR-dependent transcriptional activity in human intestinal LS180 cells by using a reporter assay. Among approximately 40 kinds of...

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PMID: 18540626
DOI: 10.1021/jf073350e

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