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Article

The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

Cancer research - 15 Oct 2001

Philp A J, Campbell I G, Leet C, Vincan E, Rockman S P, Whitehead R H, Thomas R J, Phillips W A

Abstract excerpt

Phosphatidylinositol 3'-kinases (PI3ks) are a family of lipid kinases that play a crucial role in a wide range of important cellular processes associated with malignant behavior including cell growth, migration, and survival. We have used single-strand conformational polymorphism/heteroduplex analysis to demonstrate the presence of somatic mutations in the gene for the p85alpha regulatory subunit of PI3k (PIK3R1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11606375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.PMID 11606375Read ↗

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Oncogenic mutations of PIK3CA in human cancers.Semantic proximity Read ↗

Mutation of the PIK3CA gene in ovarian and breast cancer.Semantic proximity Read ↗

PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer.Semantic proximity Read ↗

Mutation of the PI3' kinase gene in a human colon carcinoma cell line, HCC2998.Semantic proximity Read ↗

Identification of mutations in distinct regions of p85 alpha in urothelial cancer.Semantic proximity Read ↗

Mechanistic investigation of genotype-phenotype correlations in PIK3R1-related diseasesSemantic proximity Read ↗

A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.Semantic proximity Read ↗

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.Semantic proximity Read ↗

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