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Article

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.

Science (New York, N.Y.) - 13 Jul 2007

Miled Nabil, Yan Ying, Hon Wai-Ching, Perisic Olga, Zvelebil Marketa, Inbar Yuval, Schneidman-Duhovny Dina, Wolfson Haim J, Backer Jonathan M, Williams Roger L

Abstract excerpt

Many human cancers involve up-regulation of the phosphoinositide 3-kinase PI3Kalpha, with oncogenic mutations identified in both the p110alpha catalytic and the p85alpha regulatory subunits. We used crystallographic and biochemical approaches to gain insight into activating mutations in two nonca...

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PMID: 17626883
DOI: 10.1126/science.1135394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17626883-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.PMID 17626883Read ↗

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