Article
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
PloS one - 1 Jan 2013
Ross Rebecca L, Burns Julie E, Taylor Claire F, Mellor Paul, Anderson Deborah H, Knowles Margaret A
Abstract excerpt
Bladder cancers commonly show genetic aberrations in the phosphatidylinositol 3-kinase signaling pathway. Here we have screened for mutations in PIK3R1, which encodes p85α, one of the regulatory subunits of PI3K. Two hundred and sixty-four bladder tumours and 41 bladder tumour cell lines were screened and 18 mutations were detected. Thirteen mutations were in C-terminal domains and are predicted to interfere with...
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