Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

Cell cycle (Georgetown, Tex.) - 1 May 2008

Huang Chuan-Hsiang, Mandelker Diana, Gabelli Sandra B, Amzel L Mario

Abstract excerpt

Phosphatidylinositide-3-kinases (PI3K) initiate a number of signaling pathways by recruiting other kinases, such as Akt, to the plasma membrane. One of the isoforms, PI3Kalpha, is an oncogene frequently mutated in several cancer types. These mutations increase PI3K kinase activity, leading to increased cell survival, cell motility, cell metabolism, and cell cycle progression. The structure of the complex between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Cell Membrane
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Dimerization

Share to Enzyme Activation

Share to Phosphatidylinositol 3-Kinases

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 18418043
DOI: 10.4161/cc.7.9.5817
PMCID: PMC3260475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.PMID 18418043Read ↗

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.Semantic proximity Read ↗

The structural basis of PI3K cancer mutations: from mechanism to therapy.Semantic proximity Read ↗

A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.Semantic proximity Read ↗

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.Semantic proximity Read ↗

Cancer-specific mutations in phosphatidylinositol 3-kinase.Semantic proximity Read ↗

Class I PI3K in oncogenic cellular transformation.Semantic proximity Read ↗

Mutated PI 3-kinases: cancer targets on a silver platter.Semantic proximity Read ↗

Oncogenic mutations of PIK3CA in human cancers.Semantic proximity Read ↗

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.Semantic proximity Read ↗

Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.Semantic proximity Read ↗

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.Semantic proximity Read ↗

Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.