Article
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.
Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2009
Mandelker Diana, Gabelli Sandra B, Schmidt-Kittler Oleg, Zhu Jiuxiang, Cheong Ian, Huang Chuan-Hsiang, Kinzler Kenneth W, Vogelstein Bert, Amzel L Mario
Abstract excerpt
Mutations in oncogenes often promote tumorigenesis by changing the conformation of the encoded proteins, thereby altering enzymatic activity. The PIK3CA oncogene, which encodes p110alpha, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kalpha), is one of the two most frequently mutated oncogenes in human cancers. We report the structure of the most common mutant of p110alpha in complex with two...
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