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Article

p16 methylation does not affect protein expression in cervical carcinogenesis.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2008

Nehls Kristina, Vinokurova Svetlana, Schmidt Dietmar, Kommoss Friedrich, Reuschenbach Miriam, Kisseljov Fjodor, Einenkel Jens, von Knebel Doeberitz Magnus, Wentzensen Nicolas

Abstract excerpt

Previous studies have reported a frequency range of 19-61% for p16 methylation in cervical cancers. However, p16 is strongly expressed in over 90% of cervical cancers and pre-cancers, due to interactions of HPV oncogenes with p53 and pRb. In order to clarify these controversial findings, we developed a new bisulphite sequencing protocol to determine the methylation status of p16. DNA extracted from 17 cell lines...

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Share to Uterine Cervical Dysplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

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Source

Identifiers

PMID: 18722107
DOI: 10.1016/j.ejca.2008.07.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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