Article
Low frequency of BRAF and CDKN2A mutations in endometrial cancer.
International journal of cancer - 20 Jul 2005
Salvesen Helga B, Kumar Rajiv, Stefansson Ingunn, Angelini Sabrina, MacDonald Nicola, Smeds Johanna, Jacobs Ian J, Hemminki Kari, Das Soma, Akslen Lars A
Abstract excerpt
Several pathways have been implicated in the pathogenesis of endometrial carcinoma. Based on recent reports, BRAF mutations provide an alternative route for activation of the RAS signalling pathway. The CDKN2A (p16) tumour suppressor gene is also altered in several tumour types. We therefore want...
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