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Article

Restoration of the G1 checkpoint and the apoptotic pathway mediated by wild-type p53 sensitizes squamous cell carcinoma of the head and neck to radiotherapy.

Archives of otolaryngology--head & neck surgery - 1 May 1997

Chang E H, Jang Y J, Hao Z, Murphy G, Rait A, Fee W E, Sussman H H, Ryan P, Chiang Y, Pirollo K F

Abstract excerpt

BACKGROUND: A significant number of squamous cell carcinomas of the head and neck (SCCHN) resist radiation treatment, the most common form of adjuvant therapy for this disease. The presence of a mutant form of the tumor suppressor gene p53 has been correlated with disruption of programmed cell death (apoptosis) and reduced cell cycle arrest, resulting in increased radiation resistance and survival. METHODS AND...

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Source

Identifiers

PMID: 9158398
DOI: 10.1001/archotol.1997.01900050055007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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