Article
1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice.
Journal of the National Cancer Institute - 17 Oct 2001
Colussi C, Fiumicino S, Giuliani A, Rosini S, Musiani P, Macrí C, Potten C S, Crescenzi M, Bignami M
Abstract excerpt
BACKGROUND: Defective mismatch repair (MMR) in humans is particularly associated with familial colorectal cancer, but defective repair in mice is generally associated with lymphoma in the absence of experimental exposure to carcinogens. Loss of MMR also confers resistance to the toxic effects of...
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