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Article

An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.

Gastroenterology - 1 Mar 2010

Kucherlapati Melanie H, Lee Kyeryoung, Nguyen Andrew A, Clark Alan B, Hou Harry, Rosulek Andrew, Li Hua, Yang Kan, Fan Kunhua, Lipkin Martin, Bronson Roderick T, Jelicks Linda, Kunkel Thomas A, Kucherlapati Raju, Edelmann Winfried

Abstract excerpt

BACKGROUND & AIMS: Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch syndromes I and II and sporadic colorectal cancers. Msh2(null) mice predominantly develop lymphoma and do not accurately recapitulate the colorectal cancer phenotype. METHODS: We generated and examined mice with a conditional Msh2 disruption (Msh2(LoxP)), permitting tissue-specific gene inactivation. ECMsh2(LoxP/LoxP) mice carried...

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Source

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Identifiers

PMID: 19931261
DOI: 10.1053/j.gastro.2009.11.009
PMCID: PMC2862591

Genes

MSH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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