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Article

Icsbp1 /IRF-8 Is Required for Innate and Adaptive Immune Responses against Intracellular Pathogens

1 Aug 2007

Abstract excerpt

The chronic myeloid leukemia syndrome of the BXH-2 mouse strain (Mus musculus) is caused by a recessive mutation (R294C) in the transcriptional regulator Icsbp1/IRF-8. In trans activation assays using an IL-12p40 gene reporter construct introduced in RAW 264.7 mouse macrophages, we show that the Icsbp1(C294) isoform behaves as a partial loss-of-function. The Icsbp1(C294) hypomorph allele appears to have a...

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PMID: 17675508
DOI: 10.4049/jimmunol.179.4.2467

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