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Article

Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2001

Oswari J, Matthay M A, Margulies S S

Abstract excerpt

Keratinocyte growth factor (KGF) is a potent mitogen that prevents lung epithelial injury in vivo. We hypothesized that KGF treatment reduces ventilator-induced lung injury by increasing the alveolar epithelial tolerance to mechanical strain. We evaluated the effects of in vivo KGF treatment to rats on the response of alveolar type II (ATII) cells to in vitro controlled, uniform deformation. KGF (5 mg/kg) or...

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Identifiers

PMID: 11597897
DOI: 10.1152/ajplung.2001.281.5.L1068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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