Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles.

The Journal of cell biology - 30 Jun 1997

Walch-Solimena C, Collins R N, Novick P J

Abstract excerpt

The small GTPase Sec4p is required for vesicular transport at the post-Golgi stage of yeast secretion. Here we present evidence that mutations in SEC2, itself an essential gene that acts at the same stage of the secretory pathway, cause Sec4p to mislocalize as a result of a random rather than a p...

Topics

Join the communities discussing this publication.

Amino Acid Sequence
Biological Transport
Fungal Proteins
Molecular Sequence Data
Mutation
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 9199166
DOI: 10.1083/jcb.137.7.1495
PMCID: PMC2137815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9199166-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles.PMID 9199166Read ↗

The rab exchange factor Sec2p reversibly associates with the exocyst.Semantic proximity Read ↗

Cdc42 interacts with the exocyst and regulates polarized secretion.Semantic proximity Read ↗

The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p.Semantic proximity Read ↗

The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6pSemantic proximity Read ↗

New insights into the molecular mechanism of the Rab GTPase Sec4p activation.Semantic proximity Read ↗

Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.Semantic proximity Read ↗

Emerging role of Cdc42-specific guanine nucleotide exchange factors as regulators of membrane trafficking in health and disease.Semantic proximity Read ↗

Exo70p mediates the secretion of specific exocytic vesicles at early stages of the cell cycle for polarized cell growth.Semantic proximity Read ↗

Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation.Semantic proximity Read ↗

The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis.Semantic proximity Read ↗

Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex.Semantic proximity Read ↗

Cyclical regulation of the exocyst and cell polarity determinants for polarized cell growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.