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Article

Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex.

The Journal of cell biology - 15 Aug 2005

Roumanie Olivier, Wu Hao, Molk Jeffrey N, Rossi Guendalina, Bloom Kerry, Brennwald Patrick

Abstract excerpt

Rho GTPases are important regulators of polarity in eukaryotic cells. In yeast they are involved in regulating the docking and fusion of secretory vesicles with the cell surface. Our analysis of a Rho3 mutant that is unable to interact with the Exo70 subunit of the exocyst reveals a normal polarization of the exocyst complex as well as other polarity markers. We also find that there is no redundancy between the...

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Identifiers

PMID: 16103227
DOI: 10.1083/jcb.200504108
PMCID: PMC2171504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex.PMID 16103227Read ↗

The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.Semantic proximity Read ↗

Cdc42 interacts with the exocyst and regulates polarized secretion.Semantic proximity Read ↗

Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70.Semantic proximity Read ↗

Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.Semantic proximity Read ↗

Exo70p mediates the secretion of specific exocytic vesicles at early stages of the cell cycle for polarized cell growth.Semantic proximity Read ↗

The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast.Semantic proximity Read ↗

Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p.Semantic proximity Read ↗

Cyclical regulation of the exocyst and cell polarity determinants for polarized cell growth.Semantic proximity Read ↗

Exo-endocytic trafficking and the septin-based diffusion barrier are required for the maintenance of Cdc42p polarization during budding yeast asymmetric growth.Semantic proximity Read ↗

Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis.Semantic proximity Read ↗

An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components.Semantic proximity Read ↗

Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.Semantic proximity Read ↗

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