Article
Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.
Immunology letters - 1 Nov 2001
Goulder P J, Pasquier C, Holmes E C, Liang B, Tang Y, Izopet J, Saune K, Rosenberg E S, Burchett S K, McIntosh K, Barnardo M, Bunce M, Walker B D, Brander C, Phillips R E
Abstract excerpt
Cytotoxic T lymphocytes (CTL) play a central role in containment of HIV infection. Evasion of the immune response by CTL escape is associated with progression to disease. It is therefore hypothesised that transmitted viruses encode escape mutations within epitopes that are required for successful control of viraemia. In order to test this hypothesis, escape through the dominant HLA-A2-restricted CTL epitope...
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