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Article

Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness.

The Journal of infectious diseases - 15 Jan 2008

Sanchez-Merino Victor, Farrow Melissa A, Brewster Frank, Somasundaran Mohan, Luzuriaga Katherine

Abstract excerpt

In this study, amino acid sequence variation in human immunodeficiency virus (HIV)-1 Gag CD8(+) T cell epitopes was examined in untreated mother-infant pairs. Several HIV-1 CD8(+) T cell escape variants were identified within maternal plasma viral p17 and p24 sequences that were either not detected or did not persist in the plasma of their non-HLA-matched HIV-1-infected infants. Viruses constructed with each of...

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Share to CD8-Positive T-Lymphocytes
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Share to HIV Antigens

Share to HIV Core Protein p24

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Source

Identifiers

PMID: 18177249
DOI: 10.1086/524845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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