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Article

Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene.

Cancer letters - 22 Oct 2001

Hwang P H, Yi H K, Kim D S, Nam S Y, Kim J S, Lee D Y

Abstract excerpt

PTEN/MMAC1/TEP1 (PTEN) is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers, strongly suggests that PTEN alteration is possibly involved in the tumor progression and formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN gene on tumor growth...

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Source

Identifiers

PMID: 11595133
DOI: 10.1016/s0304-3835(01)00632-2

Genes

PTEN
TEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene.PMID 11595133Read ↗

Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosisSemantic proximity Read ↗

Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.Semantic proximity Read ↗

[Effects of PTEN gene on invasion and migration of ovarian cancer cell line A2780 and related mechanisms].Semantic proximity Read ↗

PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathwaySemantic proximity Read ↗

Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene.Semantic proximity Read ↗

Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancersSemantic proximity Read ↗

PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.Semantic proximity Read ↗

Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer.Semantic proximity Read ↗

Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway.Semantic proximity Read ↗

PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations.Semantic proximity Read ↗

Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas.Semantic proximity Read ↗

[A pleiotrophin-specific siRNA and its effect on PTEN-/- MEF241 cells].Semantic proximity Read ↗

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