Article
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.
Biochimica et biophysica acta - 1 Nov 2010
Kim Seaho, Huang Wei, Mottillo Emilio P, Sohail Anjum, Ham Yoon-Ah, Conley-Lacomb M Katie, Kim Chong Jai, Tzivion Guri, Kim Hyeong-Reh Choi, Wang Shihua, Chen Yong Q, Fridman Rafael
Abstract excerpt
Membrane type 1 (MT1)-matrix metalloproteinase (MT1-MMP) is a membrane-tethered MMP that has been shown to play a key role in promoting cancer cell invasion. MT1-MMP is highly expressed in bone metastasis of prostate cancer (PC) patients and promotes intraosseous tumor growth of PC cells in mice. The majority of metastatic prostate cancers harbor loss-of-function mutations or deletions of the tumor suppressor...
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