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Article

Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer.

The Journal of surgical research - 1 Oct 2013

Chowdhury Sanjib, Ongchin Melanie, Wan Guanghua, Sharratt Elizabeth, Brattain Michael G, Rajput Ashwani

Abstract excerpt

BACKGROUND: Mutational loss of tumor suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN) is associated with malignant progression in many cancers, including colorectal cancer (CRC). PTEN is involved in negatively regulating the phosphatidylinositol 3-kinase/AKT oncogenic...

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Source

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Identifiers

PMID: 23623571
DOI: 10.1016/j.jss.2013.03.035
PMCID: PMC4096772

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23623571-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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