Article
Clinical relevance of precore and basal core promoter variants of hepatitis B virus during natural hepatitis B e antigen seroconversion may be overstated.
Journal of pediatric gastroenterology and nutrition - 1 Sept 2001
Fukuda R, Mohammad R, Hamamoto S, Ishimura N, Ishihara S, Akagi S, Watanabe M, Kinoshita Y
Abstract excerpt
BACKGROUND: Clinical relevance of nucleotide changes in precore and basal core promoters in the hepatitis B virus genome during hepatitis B e antigen seroconversion may be overstated. The authors investigated the existence and changes in the relative proportion of variants to wild virus that occur with seroconversion. METHODS: Sera from 30 school-aged long-term hepatitis B virus carriers, including 11 tested...
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