Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection.

doi:10.1016/j.cmi.2015.10.033

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Article

Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Apr 2016

Zhong Y W, Di F L, Liu C, Zhang X C, Bi J F, Li Y L, Wu S Q, Dong H, Liu L M, He J, Shi Y M, Zhang H F, Zhang M

Abstract excerpt

We investigated 168 children and analysed the virological characterization and association with disease progression in children with hepatitis B virus (HBV) basal core promoter/precore (BCP/PC) mutants. Among 168 patients with HBV infection (aged 0.5-18 years old, mean 10.1), 86 of them had HBV-related liver cirrhosis (LC) and 82 had HBV-related chronic hepatitis B (CHB). A direct sequencing method was employed...

Topics

Adolescent
Child
Child, Preschool
DNA, Viral
Female
Genotype
Hepatitis B virus
Hepatitis B, Chronic
Humans
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Cirrhosis

Male

Mutation Rate

Point Mutation

Promoter Regions, Genetic

Sequence Analysis, DNA

Viral Core Proteins

Viral Load

Source

Open in PubMed

Identifiers

PMID: 26577140
DOI: 10.1016/j.cmi.2015.10.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26577140-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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